Parallel Genetic Algorithms for University Scheduling Problem

University scheduling timetabling problem, falls into NP hard problems. Re-searchers have tried with many techniques to find the most suitable and fastest way for solving the problem. With the emergence of multi-core systems, the parallel implementation was considered for finding the solution. Our approaches attempt to combine several techniques in two algorithms: coarse grained algorithm and multi thread tournament algorithm. The results obtained from two algorithms are compared, using an algorithm evaluation function. Considering execution time, the coarse grained algorithm performed twice better than the multi thread algorithm

The Approximation Szász-Chlodowsky Type Operators Involving Gould-Hopper Type Polynomials

We introduce the Szász and Chlodowsky operators based on Gould-Hopper polynomials and study the statistical convergence of these operators in a weighted space of functions on a positive semiaxis. Further, a Voronovskaja type result is obtained for the operators containing Gould-Hopper polynomials. Finally, some graphical examples for the convergence of this type of operator are given

Microglia regulate chandelier cell axo-axonic synaptogenesis

SignificanceChandelier cells (ChCs) are a unique type of GABAergic interneuron that form axo-axonic synapses exclusively on the axon initial segment (AIS) of neocortical pyramidal neurons (PyNs), allowing them to exert powerful yet precise control over PyN firing and population output. The importance of proper ChC function is further underscored by the association of ChC connectivity defects with various neurological conditions. Despite this, the cellular mechanisms governing ChC axo-axonic synapse formation remain poorly understood. Here, we identify microglia as key regulators of ChC axonal morphogenesis and AIS synaptogenesis, and show that disease-induced aberrant microglial activation perturbs proper ChC synaptic development/connectivity in the neocortex. In doing so, such findings highlight the therapeutic potential of manipulating microglia to ensure proper brain wiring

European Society of Cardiology: Cardiovascular Disease Statistics 2019

Aims The 2019 report from the European Society of Cardiology (ESC) Atlas provides a contemporary analysis of cardiovascular disease (CVD) statistics across 56 member countries, with particular emphasis on international inequalities in disease burden and healthcare delivery together with estimates of progress towards meeting 2025 World Health Organization (WHO) non-communicable disease targets. Methods and results In this report, contemporary CVD statistics are presented for member countries of the ESC. The statistics are drawn from the ESC Atlas which is a repository of CVD data from a variety of sources including the WHO, the Institute for Health Metrics and Evaluation, and the World Bank. The Atlas also includes novel ESC sponsored data on human and capital infrastructure and cardiovascular healthcare delivery obtained by annual survey of the national societies of ESC member countries. Across ESC member countries, the prevalence of obesity (body mass index ≥30 kg/m2) and diabetes has increased two- to three-fold during the last 30 years making the WHO 2025 target to halt rises in these risk factors unlikely to be achieved. More encouraging have been variable declines in hypertension, smoking, and alcohol consumption but on current trends only the reduction in smoking from 28% to 21% during the last 20 years appears sufficient for the WHO target to be achieved. The median age-standardized prevalence of major risk factors was higher in middle-income compared with high-income ESC member countries for hypertension {23.8% [interquartile range (IQR) 22.5–23.1%] vs. 15.7% (IQR 14.5–21.1%)}, diabetes [7.7% (IQR 7.1–10.1%) vs. 5.6% (IQR 4.8–7.0%)], and among males smoking [43.8% (IQR 37.4–48.0%) vs. 26.0% (IQR 20.9–31.7%)] although among females smoking was less common in middle-income countries [8.7% (IQR 3.0–10.8) vs. 16.7% (IQR 13.9–19.7%)]. There were associated inequalities in disease burden with disability-adjusted life years per 100 000 people due to CVD over three times as high in middle-income [7160 (IQR 5655–8115)] compared with high-income [2235 (IQR 1896–3602)] countries. Cardiovascular disease mortality was also higher in middle-income countries where it accounted for a greater proportion of potential years of life lost compared with high-income countries in both females (43% vs. 28%) and males (39% vs. 28%). Despite the inequalities in disease burden across ESC member countries, survey data from the National Cardiac Societies of the ESC showed that middle-income member countries remain severely under-resourced compared with high-income countries in terms of cardiological person-power and technological infrastructure. Under-resourcing in middle-income countries is associated with a severe procedural deficit compared with high-income countries in terms of coronary intervention, device implantation and cardiac surgical procedures. Conclusion A seemingly inexorable rise in the prevalence of obesity and diabetes currently provides the greatest challenge to achieving further reductions in CVD burden across ESC member countries. Additional challenges are provided by inequalities in disease burden that now require intensification of policy initiatives in order to reduce population risk and prioritize cardiovascular healthcare delivery, particularly in the middle-income countries of the ESC where need is greatest

Safer and More Efficient Parallel Cryptographic Algorithm and its Implementation in the GPU

In the digital world, the demand for data security during communication has increased. Hash functions are one of the cryptographic algorithms that provide data security in terms of data authenticity and integrity. Nowadays, most online applications require user authentication. These authentications are done on the server-side, which he must manage. As the number of applications increases, building a one-way function will be faster for calculating a hash value for small data such as passwords. In this paper, we will present a sequential cryptographic algorithm and its parallel implementation. We performed security analyses, executed comparisons for different amounts of data, and provided steps for further developing this algorithm. With the construction of this one-way function, we have provided the calculation of hash value in a shorter time for data in small quantities, which speeds up the authentication process on the server and thus speeds up the online services provided by the respective applications. A comparison was made between sequential implementation, parallel implementation on the CPU, and parallel implementation on the GPU using CUDA (Computer Unified Device Architecture) platform

Parallel Implementation of RC6 Algorithm

Data security is very important in the field of Computer Science. In this paper, the encryption algorithm called RC6 will be analyzed and its standard and parallel implementation will be done. First, the field of Cryptology is discussed in general terms, and then the classification of encryption algorithms according to operation and techniques is explained. RC6 is a symmetric block algorithm derived from the RC5 algorithm. RC6 operates on 128-bit blocks and accepts 128, 192, 256-bit keys until 2040 bytes. In the Advanced Encryption Standard (AES) competition, RC6 managed to rank among the five finalists. The structure of the RC6 algorithm will be analyzed also the encryption and decryption methods.  A comparison between standard and parallel implementation will be made

The Approximation of Bivariate Blending Variant Szász Operators Based Brenke Type Polynomials

We have constructed a new sequence of positive linear operators with two variables by using Szasz-Kantorovich-Chlodowsky operators and Brenke polynomials. We give some inequalities for the operators by means of partial and full modulus of continuity and obtain a Lipschitz type theorem. Furthermore, we study the convergence of Szasz-Kantorovich-Chlodowsky-Brenke operators in weighted space of function with two variables and estimate the rate of approximation in terms of the weighted modulus of continuity

IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

The Th17 cell-lineage-defining cytokine IL-17A contributes to host defense and inflammatory disease by coordinating multicellular immune responses. The IL-17 receptor (IL-17RA) is expressed by diverse intestinal cell types, and therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Here, we used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut. Paneth, tuft, goblet, and enteroendocrine cell numbers were dependent on IL-17A-mediated induction of the transcription factor ATOH1 in Lgr5+ intestinal epithelial stem cells. Although dispensable at steady state, IL-17RA signaling in ATOH1+ cells was required to regenerate secretory cells following injury. Finally, IL-17A stimulation of human-derived intestinal organoids that were locked into a cystic immature state induced ATOH1 expression and rescued secretory cell differentiation. Our data suggest that the cross talk between immune cells and stem cells regulates secretory cell lineage commitment and the integrity of the mucosa